Leg pain caused by Peripheral Arterial Disease (PAD) is a condition of the blood vessels that supply the legs and feet. It leads to narrowing and hardening of the arteries. This causes decreased blood flow, which can injure nerves and other tissues, causing leg pain.

Causes leg pain 3

Peripheral artery disease is caused by arteriosclerosis, or “hardening of the arteries.” This problem occurs when fatty material (plaque) builds up on the walls of your arteries and makes them narrower. The walls of the arteries also become stiffer and cannot widen (dilate) to allow greater blood flow when needed.

As a result, the muscles of your legs cannot get enough blood and oxygen when they are working harder (such as during exercise or walking). If PAD becomes severe, there may not be enough blood and oxygen, even when the muscles are resting.

Peripheral artery disease is a common disorder. It most often affects men over age 50, but women can have it as well. People are at higher risk if they have a history of:

  • Abnormal cholesterol
  • Diabetes
  • Heart disease (coronary artery disease)
  • High blood pressure (hypertension)
  • Kidney disease involving hemodialysis
  • Smoking
  • Stroke (cerebrovascular disease)

Steps to take

  1. Call to schedule a consultation: During your consultation you will be able to ask questions and have your questions answered by a medical professional. This step will help you make an informed decision for your treatment options. Call 727-475-4039
  2. Day of consultation: Please arrive 20 minutes before your appointment to fill out necessary paperwork and a health questionnaire. Bring any patient history such as previous ultrasound imaging and notes from your primary care doctor (if you have any). During your consultation you will be evaluated based on symptoms and be able to ask questions plus get knowledgeable information to help you make an informed and educated decision on vascular disease treatment and care.
  3. Return for Ultrasound: If you have not already had diagnostic image testing done, you will return for an Ultrasound and ABI (Ankle Brachial Index, a test to measure the blood pressure in your legs). This test will provide us with the knowledge on which treatment if any needs to be applied.
  4. The day of your procedure: Please arrive 20 minutes before your appointment time to fill out additional paperwork and to go over simple instructions for your return home. The minimally invasive treatments offered here at Coastal Vascular Specialists are same day procedures, so you will be returning home that day. Please be sure to have someone with you. This person will be given a prescription for pain management if necessary.

Symptoms

The main symptoms of PAD are pain, achiness, fatigue, burning, or discomfort in the muscles of your feet, calves, or thighs. These symptoms usually appear during walking or exercise, and go away after several minutes of rest.

  • At first, these symptoms may appear only when you walk uphill, walk faster, or walk for longer distances.
  • Slowly, these symptoms occur more quickly and with less exercise.
  • Your legs or feet may feel numb when you are at rest. The legs also may feel cool to the touch, and the skin may look pale.

When peripheral artery disease becomes severe, you may have:

  • Impotence
  • Pain and cramps at night
  • Pain or tingling in the feet or toes, which can be so severe that even the weight of clothes or bed sheets is painful
  • Pain that is worse when you elevate the legs and improves when you dangle your legs over the side of the bed
  • Skin that looks dark and blue
  • Sores that do not heal

Case Study in A Patient with Leg Pain and A Non-healing Open Wound

STUDY:  This is a patient with severe leg pain caused by peripheral arterial disease. The patient’s symptoms progressed to a non-healing foot ulcer on the toe. The photos below are before and after photos (angiogram) showing blood flow improvement after ultrasound guided arterial access. 

The photos show an occluded (clogged) anterior tibial artery. This artery was successfully recanalized (reopened) from a retrograde approach at the ankle accessing the dorsal pedal/anterior tibial artery. The area was successfully treated with a combination of Atherectomy and Angioplasty, and flow was successfully re-established within the anterior tibial artery.

Leg pain and foot ulcer caused by a clogged artery. Notice that the artery has been reopened.
Leg pain and foot ulcer caused by a clogged artery. Notice that the artery has been reopened.

 

Exams and Tests

During an exam, the health care provider may find:

  • A whooshing sound when the stethoscope is held over the artery (arterial bruits)
  • Decreased blood pressure in the affected limb
  • Weak or absent pulses in the limb

When PAD is more severe, findings may include:

  • Calf muscles that shrink (wither or atrophy)
  • Hair loss over the legs, feet, and toes
  • Painful, non-bleeding sores on the feet or toes (usually black) that are slow to heal
  • Paleness of the skin or blue color in the toes or foot (cyanosis)
  • Shiny, tight skin
  • Thick toenails

Blood tests may show high cholesterol or diabetes.

Tests for PAD include:

  • Angiography of the arteries in the legs (arteriography)
  • Blood pressure measured in the arms and legs for comparison (ankle/brachial index, or ABI)
  • Doppler ultrasound exam of an extremity
  • Magnetic resonance angiography or CT angiography

Treatment

Things you can do to control PAD include:

  • Balance exercise with rest. Walk or do another activity to the point of pain and alternate it with rest periods. Over time, your circulation may improve as new, small (collateral) blood vessels form. Always talk to the doctor before starting an exercise program.
  • Stop smoking. Smoking narrows the arteries, decreases the blood’s ability to carry oxygen, and increases the risk of forming clots (thrombi and emboli).
  • Take care of your feet, especially if you also have diabetes. Wear shoes that fit properly. Pay attention to any cuts, scrapes, or injuries, and see your doctor right away. Tissues heal slowly and are more likely to get infected when there is decreased circulation.
  • Make sure your blood pressure is well-controlled.
  • If you are overweight, reduce your weight.
  • If your cholesterol is high, eat a low-cholesterol and low-fat diet.
  • Monitor your blood sugar level if you have diabetes, and keep it under control.

Medicines may be needed to control the disorder, including:

  • Aspirin or a medicine called clopidogrel (Plavix), which keeps your blood from forming clots in your arteries. Do NOT stop taking these medications without first talking with your doctor.
  • Cilostazol, a drug that works to enlarge (dilate) the affected artery or arteries for moderate-to-severe cases that are not  candidates for surgery.
  • Medicine to help lower your cholesterol.
  • Pain relievers.

If you are taking medicines for high blood pressure or diabetes, take them as your doctor has prescribed.

Surgery may be performed if the condition is severe and is affecting your ability to work or do important activities, or you are having pain at rest. Options are:

  • Angioplasty and stent placement of the peripheral arteries (this is similar to the technique used to open the coronary arteries, but it is performed on the blood vessels of the affected leg)
  • Peripheral artery bypass surgery of the leg

Some people with PAD may need to have the limb removed (amputated).

Outlook (Prognosis)

Most cases of peripheral artery disease of the legs can be controlled without surgery. Although surgery provides good symptom relief in severe cases, angioplasty and stenting procedures are being used in place of surgery more and more often.

Possible Complications

  • Blood clots or emboli that block small arteries
  • Coronary artery disease
  • Impotence
  • Open sores (ischemic ulcers) on the lower legs
  • Tissue death (gangrene)
  • The affected leg or foot may need to be amputated

When to Contact a Medical Professional

Call your health care provider if you have:

  • A leg or foot that becomes cool to the touch, pale, blue, or numb
  • Chest pain or shortness of breath with leg pain
  • Leg pain that does not go away, even when you are not walking or moving (called rest pain)
  • Legs that are red, hot, or swollen
  • New sores/ulcers
  • Signs of infection (fever, redness, general ill feeling)
  • Symptoms of arteriosclerosis of the extremities

Alternative Names

Peripheral vascular disease; PVD; PAD; Arteriosclerosis obliterans; Blockage of leg arteries; Claudication; Intermittent claudication; Vaso-occlusive disease of the legs; Arterial insufficiency of the legs; Recurrent leg pain and cramping; Calf pain with exercise

References

White CJ. Atherosclerotic Peripheral Arterial Disease. In: Goldman L, Schafer AI, eds. Goldman’s Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 67.

Mills JL. Lower extremity arterial disease. In: Cronenwett JL, Johnston W, eds. Rutherford’s Vascular Surgery. 7th ed. Philadelphia, PA: Saunders Elsevier; 2010:section 15.

Creager MA, Libby P. Peripheral arterial disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, eds.Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, PA: Saunders; 2011:chap 61.

Wong PF, Chong LY, Mikhailidis DP, Robless P, Stansby G. Antiplatelet agents for intermittent claudication.Cochrane Database Syst Rev. 2011. Issue 11. Art No.: CD001272. DOI: 10.1002/14651858.CD001272.pub2.

Watson L, Ellis B, Leng GC. Exercise for intermittent claudication. Cochrane Database Syst Rev. 2008. Issue 4. Art No.: CD000990. DOI: 10.1002/14651858.CD000990.pub2.

Update Date: 5/27/2014

Updated by: Deepak Sudheendra, MD, Assistant Professor of Interventional Radiology & Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

Peripheral Artery Disease – leg pain: Article appearing on http://www.nlm.nih.gov The National Library of Medicine

 

 

 

 

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